The Biobrio 12(3&4), 2025

Mitigation of atrazine induced metabolic and oxidative dysregulation by Ocimum sanctum: An integrated experimental study

Ruchi & Dinesh Yadav

ABSTRACT:

Environmental exposure to herbicides such as atrazine has emerged as a significant toxicological concern due to its persistence and systemic effects in mammals. The present investigation provides an integrated evaluation of atrazine-induced biochemical, oxidative, and histological alterations and examines the modulatory role of Ocimum sanctum. Experimental animals were subjected to sub-chronic atrazine exposure, with parallel intervention using Tulsi extract at two graded doses. Atrazine administration resulted in pronounced metabolic imbalance, oxidative stress, and tissue degeneration, reflected in altered glucose, lipid, protein, and enzymatic profiles. Supplementation with Ocimum sanctum significantly attenuated these alterations, restoring physiological homeostasis in a dose-responsive manner. The findings highlight the central role of oxidative stress in atrazine toxicity and establish O. sanctum as a potent natural modulator of toxicant-induced dysfunction.

Keywords:    

Ocimum sanctum, Atrazine, physiological homeostasis,triazine

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