The Biobrio 2(1 & 2), 2015

IMPACTS OF ARSENIC TRIOXIDE IN SOME RENAL PARAMETERS IN ORYCTOLAGUS CUNICULUS

MANISHA KUMARI

ABSTRACT:

Arsenic is one of the most dangerous occupational and environmental toxins. Both natural and anthropogenic sources are responsible for the distribution of many toxicants, mainly heavy metals throughout the environment. Arsenic trioxide is a trivalent inorganic coumpound of arsenic. Nephrotoxicity was assessed by estimating the serum levels of Urea, Uric acid and Creatinine, the markers of renal dysfunctioning. The applied doses of arsenic trioxide administrered intraperitonially were 0.2mg/kg for 15 days and 0.6mg/kg for 7 days. Arsenic trioxide intoxication significantly increased the serum level of Urea, Uric acid and Creatinine in comparison to control due to renal dysfunctioning.

Keywords:    

Arsenic trioxide, Urea, Uric acid, Creatinine

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